conformational flexibility

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• Database of protein conformational diversity — PCDB Content Description protein conformational diversity. Contact Research center Universidad Nacional de Quilmes …   Wikipedia

• Searching the conformational space for docking — The search space consists of all possible orientations and conformations of the protein paired with the ligand. With present computing resources, it is impossible to exhaustively explore the search space; this would involve enumerating all… …   Wikipedia

• Antithrombin — Serpin peptidase inhibitor, clade C (antithrombin), member 1 Antithrombin monomer drawn from PDB 2ANT …   Wikipedia

• Morpheein — Proteins that function as morpheeins are illustrated using a dice analogy where one die can morph to two different shapes, cubic and tetrahedral. The illustrated assemblies apply a rule that the die face with one spot must contact the die face… …   Wikipedia

• Discovery and development of non-nucleoside reverse-transcriptase inhibitors — Non nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic… …   Wikipedia

• Discovery and development of HIV-protease inhibitors — Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small molecule …   Wikipedia

• Tertiary structure — In biochemistry and chemistry, the tertiary structure of a protein or any other macromolecule is its three dimensional structure, as defined by the atomic coordinates. [GoldBookRef|title=tertiary structure|file=T06282] Relationship to primary… …   Wikipedia

• X-ray crystallography — can locate every atom in a zeolite, an aluminosilicate with many important applications, such as water purification. X ray crystallography is a method of determining the arrangement of atoms within a crystal, in which a beam of X rays strikes a… …   Wikipedia

• Ring strain — is an organic chemistry term that describes the destabilization of a cyclic molecule such as a cycloalkane due to the non favorable high energy spatial orientations of its atoms. Non cyclic molecules do not exhibit ring strain because their… …   Wikipedia

• Cyclol — Figure 1: In the classic cyclol reaction, two peptide groups are linked by a N C’ bond, converting the carbonyl oxygen into a hydroxyl group. Although this reaction occurs in a few cyclic peptides, it is disfavored by free energy, mainly because… …   Wikipedia

• Dihydrouridine — IUPAC name 1 [(2R,3R,4S,5R) 3,4 dihydroxy 5 (hydroxymethyl)oxolan 2 yl] 1,3 diazinane 2,4 dione …   Wikipedia